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1

Enhancement of inflammatory mediator release by β2-adrenoceptor agonists in airway epithelial cells is reversed by glucocorticoid action

NS Holden, CF Rider, MJ Bell, J Velayudhan, EM King, M Kaur, M Salmon, MA Giembycz, R Newton

Journal:

British Journal of Pharmacology

Year:

2010

Language:

english

File:

PDF, 468 KB

english, 2010

2

Activation of guinea pig eosinophil respiratory burst by leukotriene B4: role of protein kinase C

KF Rabe, MA Giembycz, G. Dent, PJ Barnes

Journal:

Fundamental & Clinical Pharmacology

Year:

1992

Language:

english

File:

PDF, 399 KB

english, 1992

3

Choking the breath out of respiratory diseases!

Mark A. Giembycz

Journal:

Trends in Pharmacological Sciences

Year:

2001

Language:

english

File:

PDF, 37 KB

english, 2001

4

Forskolin inhibits leukotriene D4-induced thromboxane B2 release from guinea-pig lung parenchyma

Mark A. Giembycz, Ian W. Rodger

Journal:

Year:

1984

Language:

english

File:

PDF, 66 KB

english, 1984

5

Concurrent Agonism of Adenosine A2B and Glucocorticoid Receptors in Human Airway Epithelial Cells Cooperatively Induces Genes with Anti-Inflammatory Potential: A Novel Approach to Treat Chronic Obstructive Pulmonary Disease

Greer, S., Page, C. W., Joshi, T., Yan, D., Newton, R., Giembycz, M. A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2013

Language:

english

File:

PDF, 1.14 MB

english, 2013

6

Phosphodiesterase 4 Inhibitors Augment the Ability of Formoterol to Enhance Glucocorticoid-Dependent Gene Transcription in Human Airway Epithelial Cells: A Novel Mechanism for the Clinical Efficacy of Roflumilast in Severe Chronic Obstructive Pulmonary Disease

Moodley, T., Wilson, S. M., Joshi, T., Rider, C. F., Sharma, P., Yan, D., Newton, R., Giembycz, M. A.

Journal:

Molecular Pharmacology

Year:

2013

Language:

english

File:

PDF, 733 KB

english, 2013

7

Ubiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells

Smith, Susan J., Brookes-Fazakerley, Steven, Donnelly, Louise E., Barnes, Peter J., Barnette, Mary S., Giembycz, Mark A.

Journal:

American journal of physiology. Lung cellular and molecular physiology

Year:

2003

Language:

english

File:

PDF, 462 KB

english, 2003

8

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - Phosphodiesterase 4 Inhibitors Suppress Chemokine Release From Human Airway Epithelial Cells By A Novel, 15-Lipoxygenase-2- And PPARg-Dependent Mechanism

Wilson, Sylvia M., Newton, Robert, Giembycz, Mark

Year:

2012

File:

PDF, 20 KB

2012

9

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] C21. NEW TARGETS FOR ASTHMA THERAPY - TNFAlpha Reduces Glucocorticoid-Dependent Transcription: Rescue By Long-Acting Beta2-Adrenceptor Agonists And JNK Inhibition

Rider, Christopher F., Giembycz, Mark A., Newton, Robert

Year:

2011

File:

PDF, 19 KB

2011

10

[American Thoracic Society American Thoracic Society 2011 International Conference, May 13-18, 2011 â¢ Denver Colorado - ()] A68. AN ENDOCRINE STUDY OF THE LUNG: GLUCOCORTICOIDS, SEX, AND OTHER HORMONES - Pro-Inflammatory Stimuli Reduce Glucocorticoid-Dependent Transcription: A Form Of Induced Resistance To Glucocorticoids

Rider, Christopher F., King, Elizabeth M., Traves, S L., Holden, Neil S., Proud, David, Giembycz, Mark A., Newton, Robert

Year:

2011

File:

PDF, 19 KB

2011

11

PHOSPHODIESTERASE INHIBITORS: WILL THEY REPLACE THEOPHYLLINE?

Peter J Barnes, Mark Giembycz

Journal:

Clinical & Experimental Allergy

Year:

1993

Language:

english

File:

PDF, 91 KB

english, 1993

12

350 Cyclic AMP-elevating agents prolong the survival of human eosinophils in culture

HALLSWORTH, M, GIEMBYCZ, M, BARNES, P, LEE, T

Journal:

Journal of Allergy and Clinical Immunology

Year:

1996

Language:

english

File:

PDF, 97 KB

english, 1996

13

Selective Phosphodiesterase Inhibitors in the Therapy of Asthma

Gordon Dent,Dr Mark A. Giembycz

Journal:

Year:

1995

Language:

english

File:

PDF, 1.41 MB

english, 1995

14

Effect of 2-adrenoceptor agonists and other cAMP-elevating agents on inflammatory gene expression in human ASM cells: a role for protein kinase A

Kaur, M., Holden, N. S., Wilson, S. M., Sukkar, M. B., Chung, K. F., Barnes, P. J., Newton, R., Giembycz, M. A.

Journal:

AJP Lung Cellular and Molecular Physiology

Year:

2008

Language:

english

File:

PDF, 679 KB

english, 2008

15

Experimental design and analysis and their reporting II: updated and simplified guidance for authors and peer reviewers

Curtis, Michael J, Alexander, Steve, Cirino, Giuseppe, Docherty, James R, George, Christopher H, Giembycz, Mark A, Hoyer, Daniel, Insel, Paul A, Izzo, Angelo A, Ji, Yong, MacEwan, David J, Sobey, Chri

Journal:

British Journal of Pharmacology

Year:

2018

Language:

english

File:

PDF, 662 KB

english, 2018

16

Inhibition of allergen-induced lung eosinophilia by type-III and combined type III- and IV-selective phosphodiesterase inhibitors in Brown-Norway rats

W. Elwood, J. Sun, P. J. Barnes, M. A. Giembycz, K. F. Chung

Journal:

Inflammation Research

Year:

1995

Language:

english

File:

PDF, 426 KB

english, 1995

17

Putative substrates for cyclic nucleotide-dependent protein kinases and the control of airway smooth muscle tone

Mark A. Giembycz, David Raeburn

Journal:

Autonomic and Autacoid Pharmacology

Year:

1991

Language:

english

File:

PDF, 2.95 MB

english, 1991

18

Characterization of phosphodiesterase 4 in guinea-pig macrophages: multiple activities, association states and sensitivity to selective inhibitors

John J Kelly, Peter J Barnes, Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 463 KB

english, 1998

19

p38 MAP kinase and MKK-1 co-operate in the generation of GM-CSF from LPS-stimulated human monocytes by an NF-κB-independent mechanism

Koremu K Meja, Paul M Seldon, Yasuyuki Nasuhara, Kazuhiro Ito, Peter J Barnes, Mark A Lindsay, Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

2000

Language:

english

File:

PDF, 270 KB

english, 2000

20

Cyclic AMP-elevating agents prolong or inhibit eosinophil survival depending on prior exposure to GM-CSF

Matthew P. Hallsworth, Mark A. Giembycz, Peter J. Barnes, Tak H. Lee

Journal:

British Journal of Pharmacology

Year:

1996

Language:

english

File:

PDF, 1.69 MB

english, 1996

21

Phosphodiesterase 4 inhibitors delay human eosinophil and neutrophil apoptosis in the absence and presence of salbutamol

Jouni Parkkonen, Hannele Hasala, Eeva Moilanen, Mark A. Giembycz, Hannu Kankaanranta

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2008

Language:

english

File:

PDF, 251 KB

english, 2008

22

Leukotriene D4 receptors are not negatively coupled to adenylyl cyclase in guinea-pig lung parenchyma

Mark A. Giembycz, Jack Diamond, Ian W. Rodger

Journal:

British Journal of Pharmacology

Year:

1993

Language:

english

File:

PDF, 1.94 MB

english, 1993

23

Ketotifen Induces Primary Necrosis of Human Eosinophils

Hasela, Hannele, Malm-Erjefält, Monika, Erjefält, Jonas, Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Kankaanranta, Hannu

Journal:

Journal of Ocular Pharmacology and Therapeutics

Year:

2005

Language:

english

File:

PDF, 362 KB

english, 2005

24

An analysis of glucocorticoid receptor-mediated gene expression in BEAS-2B human airway epithelial cells identifies distinct, ligand-directed, transcription profiles with implications for asthma therapeutics

Joshi, T, Johnson, M, Newton, R, Giembycz, M

Journal:

British Journal of Pharmacology

Year:

2015

Language:

english

File:

PDF, 1.63 MB

english, 2015

25

Inhibition of fetal calf serum-stimulated proliferation of rabbit cultured tracheal smooth muscle cells by selective inhibitors of protein kinase C and protein tyrosine kinase.

Hirst, S J, Webb, B L, Giembycz, M A, Barnes, P J, Twort, C H

Journal:

American Journal of Respiratory Cell and Molecular Biology

Year:

1995

Language:

english

File:

PDF, 1.32 MB

english, 1995

26

An estimation of β2-adrenoceptor reserve on human bronchial smooth muscle for some sympathomimetic bronchodilators

Mark A Giembycz

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 416 KB

english, 2009

27

E-Ring 8-isoprostanes inhibit ACh release from parasympathetic nerves innervating guinea-pig trachea through agonism of prostanoid receptors of the EP3-subtype

Deborah L Clarke, Mark A Giembycz, Hema J Patel, Maria G Belvisi

Journal:

British Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 263 KB

english, 2004

28

Release of granulocyte-macrophage colony stimulating factor by human cultured airway smooth muscle cells: suppression by dexamethasone

Michael A. Saunders, Jane A. Mitchell, Paul M. Seldon, Magdi H. Yacoub, Peter J. Barnes, Mark A. Giembycz, Maria G. Belvisi

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 279 KB

english, 1997

29

Inhibitory effect of p38 mitogen-activated protein kinase inhibitors on cytokine release from human macrophages

S J Smith, P S Fenwick, A G Nicholson, F Kirschenbaum, T K Finney-Hayward, L S Higgins, M A Giembycz, P J Barnes, L E Donnelly

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 329 KB

english, 2006

30

Partial characterization of cyclic AMP-dependent protein kinases in guinea-pig lung employing the synthetic heptapeptide substrate, Kemptide: In vitro sensitivity of the soluble enzyme to isoprenaline, forskolin, methacholine and leukotriene D4

Mark A. Giembycz, Jack Diamond

Journal:

Biochemical Pharmacology

Year:

1990

Language:

english

File:

PDF, 1.79 MB

english, 1990

31

Differential Regulation of Cytokine Release and Leukocyte Migration by Lipopolysaccharide-Stimulated Primary Human Lung Alveolar Type II Epithelial Cells and Macrophages

Thorley, A. J., Ford, P. A., Giembycz, M. A., Goldstraw, P., Young, A., Tetley, T. D.

Journal:

The Journal of Immunology

Year:

2007

Language:

english

File:

PDF, 462 KB

english, 2007

32

First-generation antihistamines diphenhydramine and chlorpheniramine reverse cytokine-afforded eosinophil survival by enhancing apoptosis

Hasala, Hannele, Moilanen, Eeva, Janka-Junttila, Mirkka, Giembycz, Mark A., Kankaanranta, Hannu

Journal:

Allergy and Asthma Proceedings

Year:

2007

Language:

english

File:

PDF, 1.38 MB

english, 2007

33

[American Thoracic Society American Thoracic Society 2010 International Conference, May 14-19, 2010 • New Orleans - ()] A65. GENE EXPRESSION, PHENOTYPE, AND FUNCTION IN AIRWAY SMOOTH MUSCLE: NEW INSIGHTS - Signalling Pathways Involved In ²2-adrenoceptor Agonist Induced Relaxation Of Airway Smooth Muscle

Clarke, Deborah L., Laroumanie, Fanny, Buckley, James, Giembycz, Mark, Birrell, Mark A., Belvisi, Maria G.

Year:

2010

Language:

english

File:

PDF, 21 KB

english, 2010

34

Analysis of the Indacaterol-Regulated Transcriptome in Human Airway Epithelial Cells Implicates Gene Expression Changes in the Adverse and Therapeutic Effects of β 2 -Adrenoceptor Agonists

Yan, Dong, Hamed, Omar, Joshi, Taruna, Mostafa, Mahmoud M., Jamieson, Kyla C., Joshi, Radhika, Newton, Robert, Giembycz, Mark A.

Journal:

Journal of Pharmacology and Experimental Therapeutics

Year:

2018

Language:

english

File:

PDF, 11.88 MB

english, 2018

35

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D73. RECEPTOR INPUT OF AIRWAY NETWORKING - Synergistic Enhancement Of Glucocorticoid-Dependent Transcription By Epinephrine In The Presence Of Dexamethasone Is Predominantly Mediated Through The Â²2-Adrenoceptor

Gaunt, David D., Giembycz, Mark, Johnson, David W., Newton, Robert

Year:

2012

File:

PDF, 18 KB

2012

36

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - Phosphodiesterase 4 Inhibitors Enhance Glucocorticoid-Dependent Gene Transcription In Human Airway Epithelial Cells: A Mechanism For The Clinical Efficacy Of Roflumilast In Severe Chronic Obstructive Pulmonary Disease

Moodley, Thunicia, Wilson, Sylvia, Joshi, Taruna, Sharma, Pawan, Rider, Christopher F., Newton, Robert, Giembycz, Mark

Year:

2012

File:

PDF, 20 KB

2012

37

Inhibition of eosinophil cyclic nucleotide PDE activity and opsonised zymosan-stimulated respiratory burst by ‘type IV’-selective PDE inhibitors

Gordon Dent, Mark A. Giembycz, Klaus F. Rabe, Peter J. Barnes

Journal:

British Journal of Pharmacology

Year:

1991

Language:

english

File:

PDF, 1.48 MB

english, 1991

38

Cytokine-Induced Loss of Glucocorticoid Function: Effect of Kinase Inhibitors, Long-Acting β2-Adrenoceptor Agonist and Glucocorticoid Receptor Ligands

Rider, Christopher F., Shah, Suharsh, Miller-Larsson, Anna, Giembycz, Mark A., Newton, Robert, Wang, Zhengqi

Journal:

Year:

2015

Language:

english

File:

PDF, 75 KB

english, 2015

39

[American Thoracic Society American Thoracic Society 2012 International Conference, May 18-23, 2012 â¢ San Francisco, California - ()] D35. PHOSPHODIESTERASE INHIBITORS AS THERAPEUTICS FOR LUNG DISEASES - GS-5759, A Novel Bi-Functional Phosphodiesterase 4 Inhibitor And Long-Acting Â²2-Adrenoceptor Agonist, Inhibits CXCL9 And CXCL10 Release From Human Airway Epithelial Cells

Wilson, Sylvia M., Joshi, Taruna, Tannheimer, Stacey L., Wright, Clifford D., Salmon, Michael, Newton, Robert, Giembycz, Mark A.

Year:

2012

File:

PDF, 21 KB

2012

40

Prostaglandin E2 couples through EP4 prostanoid receptors to induce IL-8 production in human colonic epithelial cell lines

I Dey, MA Giembycz, K Chadee

Journal:

British Journal of Pharmacology

Year:

2009

Language:

english

File:

PDF, 492 KB

english, 2009

41

Prostaglandin E2 suppression of acetylcholine release from parasympathetic nerves innervating guinea-pig trachea by interacting with prostanoid receptors of the EP3-subtype

Lucia Spicuzza, Mark A. Giembycz, Peter J. Barnes, Maria G. Belvisi

Journal:

British Journal of Pharmacology

Year:

1998

Language:

english

File:

PDF, 320 KB

english, 1998

42

Characterization of the prostanoid receptor(s) on human blood monocytes at which prostaglandin E2 inhibits lipopolysaccharide-induced tumour necrosis factor-α generation

Koremu K. Meja, Peter J. Barnes, Mark A. Giembycz

Journal:

British Journal of Pharmacology

Year:

1997

Language:

english

File:

PDF, 421 KB

english, 1997

43

Role of arachidonic acid in leukotriene B4-induced guinea-pig eosinophil homotypic aggregation

Mauro M. Teixeira, Mark A. Lindsay, Mark A. Giembycz, Paul G. Hellewell

Journal:

European Journal of Pharmacology

Year:

1999

Language:

english

File:

PDF, 162 KB

english, 1999

44

Rolipram, salbutamol and prostaglandin E2 suppress TNFα release from human monocytes by activating Type II cAMP-dependent protein kinase

Paul M. Seldon, Koremu K. Meja, Mark A. Giembycz

Journal:

Pulmonary Pharmacology & Therapeutics

Year:

2005

Language:

english

File:

PDF, 218 KB

english, 2005

45

Retinoids offer hope for the treatment of emphysema

Journal:

Trends in Pharmacological Sciences

Year:

2000

Language:

english

File:

PDF, 41 KB

english, 2000

46

Delayed eosinophil apoptosis in asthma

Kankaanranta, Hannu, Lindsay, Mark A., Giembycz, Mark A., Zhang, Xianzhi, Moilanen, Eeva, Barnes, Peter J.

Journal:

Journal of Allergy and Clinical Immunology

Year:

2000

Language:

english

File:

PDF, 78 KB

english, 2000

47

Phosphodiesterase 4 Inhibitors and the Treatment of Asthma

Dr Mark A. Giembycz

Journal:

Year:

2000

Language:

english

File:

PDF, 312 KB

english, 2000

48

Evidence for a Second Receptor for Prostacyclin on Human Airway Epithelial Cells That Mediates Inhibition of CXCL9 and CXCL10 Release

Wilson, S. M., Sheddan, N. A., Newton, R., Giembycz, M. A.

Journal:

Molecular Pharmacology

Year:

2011

Language:

english

File:

PDF, 2.01 MB

english, 2011

49

Prostaglandin E2 Represses Interleukin 1 Beta-Induced Inflammatory Mediator Output from Pregnant Human Myometrial Cells Through the EP2 and EP4 Receptors

Mosher, A. A., Rainey, K. J., Giembycz, M. A., Wood, S., Slater, D. M.

Journal:

Biology of Reproduction

Year:

2012

Language:

english

File:

PDF, 442 KB

english, 2012

50

Biochemical and pharmacological interactions between the papaverine derivative, AH 21–132, and methacholine in bovine tracheal smooth muscle

M.A. Giembycz, E.R. Chilvers, P.J. Barnes

Journal:

European Journal of Pharmacology

Year:

1990

Language:

english

File:

PDF, 243 KB

english, 1990

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